There are three changes from the XI that started Sunday's Emirates FA Cup clash with Fulham, with Harry Maguire and Manuel Ugarte - who both picked up knocks in that game - replaced by Patrick Chinazaekpere Dorgu and Casemiro.
The third alteration sees Alejandro Garnacho come in for Christian Eriksen, who is one of Amorim's seven substitutes for the 17:45 GMT kick-off at the Reale Arena in San Sebastian.
It means Andre Onana resumes in goal, with Noussair Mazraoui a prime candidate to drop into the three-man defence and line up alongside centre-backs Matthijs de Ligt and Leny Yoro, if we are to set up in Ruben's favoured 3-4-2-1 system.