James Garner makes his first start in midfield, while Ole sticks with three at the back - a system he employed in Sunday's draw against Liverpool.
Phil Jones is drafted in to replace Victor Lindelof in the backline, with Harry Maguire and Marcos Rojo keeping their places. Summer signing Maguire captains the side for the first time.
Aaron Wan-Bissaka and Brandon Williams will be asked to provide the width as attacking full-backs.
Garner, who has added goals to his game this term and been in magnificent form for the Under-23s, has only had a few seconds of first-team experience - as a late substitute at Crystal Palace last February.