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Manchester United defenders Chris Smalling and Phil Jones suffered "long-term injuries" while on duty with England, Jose Mourinho has said.
Smalling, 27, withdrew from the England squad with an undisclosed injury and was later photographed wearing a leg brace.
Jones also pulled out of the England squad after damaging his toe in a training ground challenge with Smalling, meaning Eric Bailly and Marcos Rojo are likely to start in central defence against West Brom on Saturday.