Pablo Dybala hit the only goal of the game last month when the Serie A holders claimed a 1-0 victory at Old Trafford, to maintain their 100 per cent winning record in the competition this season.
The Reds are eager to bounce back and pick up a result to boost chances of qualification from Group H, ahead of upcoming meetings against Young Boys and Valencia. Let's take a closer look at an intriguing contest...
Any United team news?
Alexis Sanchez and Jesse Lingard both missed October's match against Juventus, but returned to the matchday squad for Saturday's trip to Bournemouth.