Ole Gunnar Solskjaer's men sealed a memorable come-from-behind victory over the Italian side last month at Old Trafford to claim top spot in Group F on six points.
Things remain very tight across all four teams in the group - Villarreal sit level with Atalanta on four points, while bottom-placed Young Boys are on three. With two home wins under our belt, the Reds are looking to claim a first away victory of this season's European campaign against a side Bruno is fully familiar with, having faced them during his time with Udinese.
We sat down with our Portuguese magnifico to look ahead to our latest test against Atalanta and also asked him about the form of our strikers and his feelings on being nominated for the prestigious Ballon d'Or.