The boss has made six changes from the 3-2 win over Bodo/Glimt in the Europa League and, as is the case at the moment, it is difficult to be sure on the exact positioning of certain players.
Joshua Zirkzee or Marcus Rashford could lead the line with both options to fill the centre-forward slot.
Kobbie Mainoo returns to make his maiden appearance under Amorim, while Amad could start at wing-back again, after performing well in the role during the 1-1 draw at Ipswich Town last weekend.
Harry Maguire is back in the squad, and among the substitutes, after, like Mainoo, being absent since the goalless draw at Aston Villa on 6 October.