We've faced the side from the Spanish capital just twice before in our history – a Cup Winners' Cup tie in 1991/92 which the Spaniards won 4-1 on aggregate.
The Madrid side have been one of the most consistent clubs in European football in recent years, winning two La Liga titles and reaching the Champions League final in two occasions. They also won the Europa League in 2010, 2012 and 2018.
It's sure to be a fascinating tie, and here's why...
RONALDO RETURNS TO MADRID
This will be the first time that Ronaldo has faced a Madrid club since he returned to Old Trafford last summer, and his record against Atletico suggests he'll be looking forward to the reunion.