The 20:15 GMT kick-off is certainly a tantalising prospect. Hosts Arsenal have been in free-scoring form since returning from the November international break, putting away 13 goals in three games. United, meanwhile, have eight goals to our name, having struck four times against Everton to give Amorim a second successive Old Trafford win last week.
This league fixture also acts as something of a teaser to the FA Cup third round, where we've been drawn against the Gunners in north London. That cup tie will be played in early January next year.
Ahead of the match, we've been playing our United Predictions game alongside MUTV pundits Wes Brown and Danny Webber.