The Reds take on Ruud van Nistelrooy's Foxes in a 20:00 GMT kick-off, after dumping Arsenal out of the competition at the previous stage.
Lisandro Martinez is absent, after suffering a knee injury during last weekend's game against Crystal Palace. A club statement confirmed a cruciate-ligament issue will rule the in-form Argentina international out of action.
Fellow left-sided defender Luke Shaw is also being treated carefully and will not be rushed back.
"Licha is a difficult situation," Amorim said at his pre-match press conference at Carrington. "He’s going to be out for a while.