The Reds are looking for three points against Kieran McKenna's side, after drawing the reverse fixture 1-1 in Amorim's opening game in charge.
After some below-par form at Old Trafford recently, the hosts will be determined to give the crowd something to cheer in the 19:30 GMT kick-off, which is live on TNT Sports in the UK.
There are two changes to the side that started the 2-2 draw at Everton last time out.
Noussair Mazraoui appeared to pick up a knock at Goodison Park and is only on the bench, with Leny Yoro drafted into the three-man defence.