The Reds are looking for a boost after successive defeats in the Premier League, to Everton and Nottingham Forest, but picked up a valuable away victory in the Europa League on Thursday, against Viktoria Plzen.
City have a formidable home record but suffered a shocking 4-0 loss to Spurs recently, and it will be interesting to see how things pan out in the 16:30 GMT kick-off.
Mason Mount is rewarded for a bright cameo in the Czech Republic with a start and Amad looks set to continue in a more advanced role, with Noussair Mazraoui and Diogo Dalot likely to feature as wing-backs.