The boss had little option after the euphoric, bur gruelling, Europa League quarter-final victory over Lyon late into Thursday night.
He has said he will carefully manage players' minutes, with the priority clearly the last-four dates in Europe with Athletic Club next month.
There are five alterations to the XI that started the epic tie with Lyon, including a senior debut for Tyler Fredricson in defence.
The homegrown centre-back is joined by Victor Lindelof, who captains the team, and Noussair Mazraoui, who was withdrawn at half-time on Thursday due to a personal issue.
Kobbie Mainoo is rewarded for his heroics with a start, possibly in an advanced slot, while Harry Amass is in too, probably ensuring Patrick Chinazaekpere Dorgu swaps flanks.