Alejandro Garnacho starts, following his fine cameo against Leicester City in the Emirates FA Cup, while Casemiro replaces the absent Kobbie Mainoo (injured) in midfield.
Amad revealed yesterday that he has picked up an ankle injury that will keep him out for some time, so Joshua Zirkzee joins Rasmus Hojlund in attack.
The fourth change is Matthijs de Ligt, who returns in place of Leny Yoro (ill), while there's also a fascinating substitutes line-up, which includes six Academy graduates.
Chido Obi is named in a matchday squad for the first time, following his hat-trick in the FA Youth Cup victory over Chelsea, and is joined by fellow youngsters Elyh Harrison, Harry Amass, Tyler Fredricson, Jack Fletcher and Jack Moorhouse,
January Ayden Heaven is also among the subs, as is midfielder Sekou Kone, and joining them is one senior member of the squad: Victor Lindelof.