Ruben Amorim has selected the Manchester United side for his first Anfield assignment as head coach.
The Reds may be the underdogs heading into the encounter with Premier League leaders Liverpool, considering the contrasting form of the two sides.
However, Amorim will hope his XI can spring a surprise on Merseyside, with the game kicking off at 16:30 GMT despite the snow and freezing conditions affecting most of the UK, including areas throughout the north west.
Manuel Ugarte and Bruno Fernandes return from the suspension that ruled them out of the defeat to Newcastle United last Monday, with both midfielders back in the starting line-up.