The Manchester United midfielder is set to represent his country at the Estadio Municipal de El Alto, which is situated around 4,1000 metres above sea level.
El Alto, which is Spanish for 'The Heights', is known as the highest major city in the world and the second-largest in Bolivia, after the administrative capital La Paz.
It is always difficult to play at altitude and this is set to provide a taxing examination of Marcelo Bielsa's side, who have slipped to fourth in the South American table. Hosts Bolivia are in seventh, while there is also a huge game between Argentina and Brazil taking place in Buenos Aires.