The blockbuster clash, which kicks off at 12:30 GMT, sees two of the leagues top four sides lock horns. But this one is about more than just three points.
Before the match, United captain Katie Zelem and head coach Marc Skinner sat down with MUTV’s Zarah Connolly to preview the fixture, and Manchester-born Zelem is looking forward to it in particular.
“Yeah, I can’t wait,” she said. “We all know what Manchester derbies are about and we’ve got a few new players in the team this year so it’s about telling them what the experience is going to be like.