Trailing 2-0 at the interval to goals from Jan Bednarek and James Ward-Prowse, we also lost David De Gea to injury but Dean Henderson came on to make his Premier League debut for the club and Edinson Cavani replaced Mason Greenwood in attack.
Not for the first time against the Saints, United refused to buckle and the never-say-die attitude sparked a tremendous turnaround.
Bruno Fernandes provided hope by turning in a Cavani centre before the Uruguayan took centre stage, netting two headers, the second in the dying seconds, to supply a real boost ahead of the visit of his former employers Paris Saint-Germain in midweek.