Manchester City's hopes of winning the quadruple were ended after the succumbed to a 1-0 defeat at League One Wigan.
Will Grigg's second-half strike saw the Latics earn a place in the FA Cup quarter-finals on a contorversial night at the DW Stadium.
Earlier, Fabian Delph was sent off for a challenge on Max Power which saw City boss Pep Guardiola get into a spat with Wigan boss Paul Cook.
From that point, the home side grew in confidence and Grigg's guided finish was enough to knock the 2011 winners out of the competition.