Vincent Kompany makes his first Premier League start of the season for Manchester City against Southampton, while Sergio Aguero returns after being dropped against Barcelona.
Kompany, City's captain, returned from a groin problem with a brief substitute appearance against Everton last weekend but did not make the matchday squad for Wednesday's Champions League game at the Camp Nou.
Kompany's City career has been blighted by muscle injuries, the latest being a groin problem suffered at Swansea in the EFL Cup last month on his comeback from a previous layoff.
"I will use my experience to get through the day, I am excited.