Liverpool's 5-1 thumping of Arsenal on Saturday means that Manchester City simply must win at Southampton.
Pep Guardiola's side will kick-off Sunday's game at St Mary's 10 points behind the Premier League leaders, whom they face in their first match of 2019 on January 3.
Kick-off on the South Coast is at 2.15pm and Sportmail will be providing live updates below.
We will also keep you posted about what is happening between Burnley and West Ham in the day's other 2.15pm match.
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