Sergio Aguero has been ruled out of Manchester City's clash against Crystal Palace this weekend while Claudio Bravo will not play again this season.
Manager Pep Guardiola has also revealed playmaker David Silva remains a doubt despite returning to training and defender John Stones is still sidelined.
Aguero, City's top scorer with 31 goals this term, suffered a groin injury in the latter stages of last week's draw at Middlesbrough and has been unable to prove his fitness for Saturday's Premier League visit of Palace.
Guardiola, asked about Aguero's fitness at his latest press conference, said: "No.