Chelsea have been drawn against Real Madrid in the Champions League quarter-finals, while Manchester City will take on Atletico Madrid and Liverpool play Benfica.
Bayern Munich face Villarreal in the other last eight tie.
Chelsea and Man City would meet in the semi-finals if they both overcome their Madrid opposition, while Liverpool could meet Bayern in the last four.
The Blues overcame Real in last season's semi-finals en route to winning the competition, while Atletico face a swift return to Manchester having just eliminated Man United in the round of 16.