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Best of enemies Messi and Ramos team up against Real Madrid, Chelsea meet Lille in the 'Joe Cole derby' and Ronaldo LOVES playing Atletico... but can Man United really threaten them? Why we can't wait for the Champions League to return

The Champions League, finally, is back this week in a move that signals the season ramping up into the business part of the campaign.

Europe's elite cross paths once again with the first half of the last-16 ties taking place this week and the others getting underway next week.

Sportsmail looks at some of the major talking points of the ties that are about to get going.

Chelsea's defence of their Champions League title continues against Lille in the last-16

MESSI, RAMOS AND MBAPPE TAKE ON MADRID

In their pomp at Barcelona and Real Madrid respectively, Lionel Messi and Sergio Ramos often clashed in the El Clasico showdowns between Spain's two major sides.