Don't check my math, but I'm pretty sure that means you would have to wager $2 billion to make $2.50.
The bad news is that after last week's events, the Louisville football team's national championship odds have fallen from 9/1 to 14/1, making them the 6th choice to win it all.
From Bovada:
Odds to Win the 2017 CFP National Championship
Team 10/31/16 Current Odds (11/6/16)
Alabama 8/5 11/10
Ohio State 5/1 19/4
Michigan 11/2 5/1
Clemson 5/1 15/2
Washington 9/1 9/1
Louisville 9/1 14/1
Auburn 50/1 20/1
Wisconsin 33/1 25/1
Oklahoma 40/1 40/1
Oklahoma State 150/1 66/1
West Virginia 75/1 66/1
Florida 40/1 100/1
Virginia Tech 150/1 100/1
Baylor 75/1 Off the Board
LSU 25/1 Off the Board
Nebraska 50/1 Off the Board
Texas A&M 33/1 Off the Board
Odds to win the 2016 Heisman Trophy
Player 10/31/16 Current Odds (11/6/16)
Lamar Jackson (QB Louisville) 1/3 1/20
Jabrill Peppers (S Michigan) 9/2 12/1
Deshaun Watson (QB Clemson) 9/2 12/1
Jake Browning (QB Washington) 20/1 14/1
JT Barrett (QB Ohio State) 33/1 50/1
Jalen Hurts (QB Alabama) 33/1 Off the Board
Dalvin Cook (RB Florida State) 50/1 Off the Board