The St. Louis Rams (4-7) are back in the Edward Jones Dome, as they host their rivals the Arizona Cardinals (9-2). The Rams have already beaten the Cardinals in Week 4 of the 2015 season; however the Rams will have their hands full with the Cardinals this team around. Rookie running back Todd Gurley was in the spotlight during the first meeting as he totaled 146 rushing yards in his first start at running back. Wide receiver Tavon Austin also got the offense going with 96 receiving yards with two touchdowns.
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However this time around, Gurley could be getting the ball from a new quarterback under center.