4:25 p.m. ET | CBS
Matchup rating: 57.4 | Spread: ARI -3 (40.5)
What to watch for: The Rams have won seven straight against the Cardinals under coach Sean McVay, and despite an injury-depleted offense, a top-ranked defense makes eight possible. Watch for defensive tackle Aaron Donald and cornerback Jalen Ramsey to wreak havoc against quarterback Kyler Murray and his arsenal of playmakers. In Week 10, Murray was sacked twice and limited to 173 passing yards, though he did toss three touchdowns.