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Reggie Bush ruled out with knee injury (The Associated Press)

San Francisco 49ers running back Reggie Bush is attended to by a trainer after he slipped out of bou …

San Francisco 49ers running back Reggie Bush (23) runs with the ball as St. Louis Rams linebacker Da …

ST. LOUIS (AP) -- San Francisco 49ers running back Reggie Bush has been carted off the field with a knee injury after slipping on concrete near the stands on a punt return and will not return.

Bush was making his first start of the season in place of the injured Carlos Hyde.