In a game featuring two teams heading in different directions, the Rams (4-7) take on the Arizona Cardinals (9-2) in a noon Sunday game at the Edwards Jones Dome.
The Rams, who entered November above .500 for the first time since 2006, dropped all four contests last month. Meanwhile, the Cardinals have won five in a row and six of seven since losing 24-22 to the visiting Rams on Oct. 4.
Arizona enters Sunday's action with a three-game lead atop the NFC West. The Rams are 3-0 against division foes this season.
Both teams enter dealing with significant injuries.