Ryan, sacked 15 times in four games, has the team at 1-2-1 in his first season with the Colts, following one-and-done starters Carson Wentz (2021), Philip Rivers (2020), Jacoby Brissett (2019) and the final season from Andrew Luck (2018).
Indianapolis lost to the Tennessee Titans 24-17 on Sunday.
Offense has been hard to come by for the Colts, who are last in the AFC with 57 points and ahead of only the 49ers (47 points entering their Week 4 game Monday night).
"Not an excuse, but every year we have a new quarterback. So each year we have growing pains while we sit here and watch Tennessee, which has had (Ryan) Tannehill, what, my whole career?