Even as the San Francisco 49ers have regressed since their most recent Super Bowl appearance, they've remained quick starters; the Niners are 5-0 both straight up and against the spread over their last five season openers.
This year San Francisco opens with a renewal of a great West Coast football rivalry when it hosts the Rams of Los Angeles on Monday night at Levi's Stadium in Santa Clara.
Point spread: Rams opened as 2.5-point favorites; the total was 47 early in the week, according to sportsbooks monitored by Odds Shark. (Line updates and matchup report)
NFL pick, via Odds Shark computer: 23.