Over the last three seasons, the San Francisco 49ers have controlled the rivalry against the Los Angeles Rams. The Rams are 0-6 against the 49ers in the regular season since 2019. The last win in the regular season against the 49ers for the Rams came all the way at the end of 2018.
Sean McVay has not had a lot of success against the Kyle Shanahan in recent years. However, he finally got over the hump in the NFC Championship Game back in January. The Rams won that game 20-17 on their way to the Super Bowl.