ESPN Chalk's Vegas experts are here to provide analysis and best bets for all Week 1 games, including the Los Angeles-San Francisco matchup.
Note: Odds courtesy of the Westgate Las Vegas SuperBook as of Sunday afternoon.
Spread: Opened Los Angeles -2.5; now Los Angeles -2.5
Total: Opened47; now 47.5
PickCenter public consensus pick: 71 percent Los Angeles