During the 2018 NFL season, the Los Angles Rams traveled East of the Mississippi River twice, week 9 against the New Orleans Saints and week 13 against the Detroit Lions. Their travel schedule was extremely friendly and probably benefited the Rams to some degree.
The 2019 NFL season won’t be nearly as kind. Three of the Rams first eight games take them into Eastern Standard Time with another taking them to London. Of those four games, three will be played at 10A PST, which has traditionally been difficult for West coast teams to overcome.