The Rams were driving at the end of the first quarter, reaching the Colts' 21 before a facemask call on guard Demetrius Rhaney and a sack by Indy's Erik Walden (around rookie right tackle Rob Havenstein) killed the drive and the Rams were forced to punt.
Isaiah Pead downed the Johnny Hekker punt at the Colts' 5 and the defense took over from there, getting in-the-backfield tackles from starting DTs Michael Brockers and Aaron Donald on successive plays to force Indianapolis to punt from its 1.
After the punt, the Rams' first down play from the Colts' 44 was a Nick Foles bomb to Chris Givens on a deep crossing pattern for a touchdown TD.