San Francisco 49ers quarterback Trey Lance was carted off the field with an air cast on his lower right leg late in the first quarter of Sunday's game against the visiting Seattle Seahawks in Santa Clara, Calif.
Lance's leg appeared to buckle under him after a short gain on a rushing play. He was quickly ruled out for the game with an ankle injury.
Jimmy Garoppolo entered the game in relief of Lance and started 4-for-4 for 70 yards, capped off by a 38-yard touchdown pass to tight end Ross Dwelley that gave the 49ers a 13-0 lead early in the second quarter.