Both of these teams played in overtime in Week 1 but they had very different results. The Chargers got off to a great start by defeating the Indianapolis Colts while the Detroit Lions had to settle for a tie with the Arizona Cardinals in a game that should have never even gone to overtime.
A win over the Lions would give the Chargers their first 2-0 start since 2012.
Series history
The Chargers lead the all-time series and have won two of the last three games played in Detroit. Overall, the Chargers have beaten the Lions seven of eight times dating back to September 1981.