Coming out of Allen High School as a four-star recruit, Guyton initially committed to Notre Dame where he redshirted his only year on campus. He was dismissed for an “undisclosed reason” and promptly transferred away from South Bend.
Guyton ended up at North Texas where he had to sit out the 2016 season due to NCAA transfer guidelines. During his first year of action for the Mean Green, Guyton was named a Second-Team All-CUSA honoree after catching 49 passes for 775 yards and nine touchdowns. As a junior in 2018, Guyton improved on most of his stats by collecting 54 catches for 805 yards and six touchdowns.