After a pair of ineffective plays, the opening drive looked like a lost cause on 3rd & 8 until Geno Smith scrambled for a 1st down. A roughing the passer penalty and a 20-yard scramble moved the Chargers into 49ers territory. A 10-yard Newsome run kept the drive moving, but it eventually stalled out and Roberto Aguayo came on to kick a 36-yard field goal making him 2 for 2 during the preseason.
Derwin James showed up immediately on the 49ers first snap with a run stop against Alfred Morris after 2 yards.