Liverpool's Virgil van Dijk, Manchester City's Nathan Ake and Manchester United's Tyrell Malacia have been named in the Netherlands squad for the World Cup in Qatar.
Simons has scored eight goals in 13 league games for PSV Eindhoven.
United midfielder Donny van de Beek has not been picked by coach Louis van Gaal.
Veteran NEC Nijmegen goalkeeper Jasper Cillessen, 33, has also been overlooked.
The World Cup runs from 20 November to 18 December.
The Netherlands play Senegal on 21 November, Ecuador on 25 November and Qatar on 29 November in Group A.
Netherlands squad:
Goalkeepers: Justin Bijlow (Feyenoord), Andries Noppert (Heerenveen), Remko Pasveer (Ajax).