The Reds head into the match off the back of a 1-0 win at Brighton and Hove Albion, while the Eagles lost 2-1 at home to Watford last weekend.
Liverpool triumphed 2-0 in a hard-fought game at Selhurst Park earlier in the season, but what can we expect from the south London club this time around?
We caught up with Back of the Nest Preview Podcast host and RedNBlueArmy editor Terence Ford (@RedNBlueArmy1) to find out.
What's your progress report since we met in the second game of the season?
The first half of the season was one of frustration for most Palace fans.