Liverpool last faced Real Madrid just nine months ago when the Spanish giants claimed their ninth Champions League/European Cup with a 1-0 victory in Paris.
Meeting again in the last-16 of this year's edition of the competition, it promises to be one of the ties of the round with one of Europe's true heavyweights exiting the competition before daffodils have begun to bloom.
Liverpool, who enjoyed one of their most important wins of the season on Saturday at Newcastle, go into the game with confidence.
While Real Madrid head to Anfield knowing they have not been defeated by the English side since 2009, when Rafa Benitez was in charge.