Former Manchester City boss and 2013-14 Premier League winner Manuel Pellegrini has replaced David Moyes in the dugout, while club-record signing Felipe Anderson heads a list of nine new players snapped up during the transfer window.
So, what can we expect from a much-changed Hammers side at Anfield? West Ham expert, season ticket holder and blogger Vinny Ryan has the answers...
There was disquiet among sections of the West Ham fans last season - has the arrival of a new manager and new players altered expectations for 2018-19?
West Ham fans are a passionate bunch and we are fiercely proud of our club, so to have lost our home was hard for many to take.