The visitors head into the first-ever meeting between the clubs sitting top of Group E having beaten Genk 6-2 on matchday one.
Salzburg won their sixth successive Austrian Bundesliga title last season and are in pole position once again this term, despite changing managers in the summer.
So, what can we expect from Sadio Mane and Naby Keita's former club at Anfield? We spoke to Austrian football expert Tim Armitage (@FussballTim_) to find out...
Tell us about new manager Jesse Marsch. How do the fans view him?
Marsch, a former USA national team player, took his first management job in 2012, but it wasn't until 2015 that he joined the Red Bull franchise, taking the reins of New York Red Bulls for three years before making the move to Germany, where he became Ralf Rangnick's [former sports director for Salzburg] assistant at Leipzig.