The Reds overcame Bayern Munich in the previous round after a headline-grabbing 3-1 win at the Allianz Arena, while Porto beat Italian side AS Roma 4-3 over two legs.
Liverpool faced the Portuguese side in the Round of 16 of the competition only last season, when Jürgen Klopp's men ran out 5-0 winners en route to the Champions League final in Kiev.
Meanwhile, opposition boss Sergio Conceicao went on to guide Os Dragoes to their first Primeira Liga title for five years and is currently vying with Benfica for a repeat triumph this term.
So, what can we expect from Porto at Anfield on Tuesday?