Separated only by goal difference, victory for either side would see them move clear of their rivals at the top of the table.
The clubs met four times across all competitions last season, with Jürgen Klopp's Reds beating Pep Guardiola's team on three of those occasions, including both legs of their Champions League quarter-final.
With both sides neck-and-neck in the league this term, what can we expect from the visitors this time around?
We spoke to journalist, author and City fan Simon Curtis (@bifana_bifana) to get the lowdown...
Why do the Reds seem to cause City so many problems?