The Academy graduates come into the line-up at the bet365 Stadium along with Joel Matip, meaning Woodburn makes his first ever top-flight start and Alexander-Arnold only his second.
Roberto Firmino and Lucas Leiva drop down to the bench, while Philippe Coutinho has been passed fit enough to join them among the substitutes after illness.
Liverpool: Mignolet, Clyne, Klavan, Matip, Lovren, Milner, Can, Wijnaldum, Alexander-Arnold, Woodburn Origi. Subs: Karius, Moreno, Grujic, Sturridge, Firmino, Lucas, Coutinho.