forward Nolito has failed a fitness test ahead of Sevilla's Champions League clash with Liverpool on Wednesday.
The Spaniard moved to the La Liga club from the Etihad in July for around £8m after struggling to adapt to life in the Premier League.
He was set to return to England this week, though, with Sevilla as they take on Liverpool in the Champions League.
However, Nolito has now been ruled out of the match at Anfield due to a thigh injury.
Fellow new signing Johannes Geis, who arrived on loan from Schalke on deadline day, will also be absent.