After scoring as a substitute at Arsenal on Saturday, the Portugal forward is named in the XI at Estadio Alfredo Di Stefano as the Reds make three changes.
Georginio Wijnaldum and Naby Keita also begin, with Roberto Firmino, Thiago Alcantara and James Milner dropping to the bench.
Liverpool: Alisson, Alexander-Arnold, Phillips, Kabak, Robertson, Fabinho, Wijnaldum, Keita, Mane, Salah, Jota.
Subs: Adrian, H. Davies, Thiago, Milner, Firmino, Oxlade-Chamberlain, Jones, Tsimikas, Shaqiri, B. Davies, R. Williams, Cain.