The centre-back, signed from Southampton earlier this week, is named in the Reds' starting XI as Jürgen Klopp makes six changes to the team deployed at Burnley on New Year's Day.
Sadio Mane begins alongside Roberto Firmino and Alex Oxlade-Chamberlain in attack after flying back overnight from the CAF African Player of the Year awards in Ghana on Thursday.
Elsewhere, Loris Karius has been given the nod in goal while Joel Matip, Andy Robertson and James Milner also return to the line-up.
Liverpool: Karius, Gomez, Matip, Van Dijk, Robertson, Milner, Can, Lallana, Oxlade-Chamberlain, Mane, Firmino.