Nathaniel Clyne, Fabinho, Dejan Lovren, Simon Mignolet and Alberto Moreno are all named in Jürgen Klopp’s XI at Anfield.
Joel Matip and Xherdan Shaqiri retain their places from Saturday’s win over Southampton while Naby Keita and Daniel Sturridge return to the line-up.
James Milner captains the Reds in the third-round tie and Academy starlet Curtis Jones is on the bench.
Liverpool team: Mignolet, Clyne, Lovren, Matip, Moreno, Fabinho, Milner, Keita, Shaqiri, Mane, Sturridge.
Substitutes: Grabara, Firmino, Salah, Gomez, Henderson, Solanke, Jones.